About ClonOrgan-ClonOrgan

About ClonOrgan

Company Profile

China's Leading Xenotransplantation Enterprise

ClonOrgan Biotechnology Co., Ltd. (hereinafter referred to as "ClonOrgan") is China's leading xenotransplantation enterprise, co-founded by the national-level talent team of Prof. Dengke Pan and Prof. Shaoping Deng. ClonOrgan is long-term dedicated to the in-depth R&D of xenotransplantation donor pigs, cultivating China's largest herd of gene-edited low-immunogenicity donor pigs, developing therapeutic technologies using transplantable pig kidneys, livers, hearts, skin, red blood cells, and more, achieving a breakthrough in the entire industry chain technology from gene-edited pigs to the clinical application.

Corporate History

2005

Prof. Dengke Pan

Developed China's first somatic cell cloned pig

Awarded the National Science and Technology Progress Award (Second Prize)

2010

Dengke Pan team

Developed China's first GTKO (α1,3-galactosyltransferase knockout) pig

2018

Established ClonOrgan Biotechnology

Developed over 10 gene-edited pig lines

2020

Established China's first gene-edited miniature pig breeding base

(Neijiang)

2022

Established China's first ultra-clean DPF (Designated Pathogen-Free) breeding center for gene-edited miniature pigs (Neijiang)

2023

kidney transplantation into brain-dead human recipients using gene-edited pigs

2024

Completed world's first

liver xenotransplantation from a gene-edited pig into a brain-dead human recipient

2025

kidney transplantation into a patient, with post-transplant survival exceeding 5 months

2027

Projected clinical trial approval for gene-edited pig kidney xenotransplantation

Qualifications and Honors

Demonstration Base for Medical Pig Disease Prevention and Control (National Pig Technology Innovation Center, 2023)
Medical Pig Xenotransplantation Cooperation Base
(National Major Scientific and Technological Infrastructure – Model Animal (Pig), July 2023)
Xenotransplantation and Regeneration Key Laboratory of Sichuan Province
"Specialized, Refined, Unique, and Innovative" SME of Sichuan Province
High-Tech Enterprise(Sichuan Province)
Vice Chair Unit of Sichuan Provincial Association for Laboratory Animal Science

ClonOrgan–Sichuan Agricultural University Industry–University–Research Joint Laboratory (Chengdu)
Public Technology Platform for Gene Editing and Somatic Cell Cloning（Chengdu High-tech Zone）
Gene Editing and Large Animal Human Disease Model Innovation Service Platform（Chengdu High-tech Zone）
Seed-Stage Eaglet Enterprise（Chengdu High-tech Zone）
High-Level "Four-Talent" Enterprise（Chengdu High-tech Zone）

资质证书

Corporate Culture

Mission

To care for life and contribute to human health and longevity!
Goal

To become a leading enterprise in the global xenotransplantation donor pig industry.
Values

Adhering to passion, never forget the original aspiration, conduct business with kindness.
Motto

Innovation and Pragmatism, Rigor and Efficiency, Striving and Dedication.

Scientific Committee

Prof. Leo Hans Bühler
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Prof. Shaoping Deng
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Prof. Dengke Pan
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Prof. Gang Chen
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Prof. Yi Wang
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Prof. Hidetaka Hara
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Prof. Leo Hans Bühler

M.D., Ph.D., Chair of the Scientific Committee

· Former President, International Xenotransplantation Association (IXA)

· Editor-in-Chief of Xenotransplantation (since 2012)

· Director, Department of Surgical Research, University and Hospital of Fribourg, Switzerland

· Author of 270+ Peer-Reviewed Papers and 10+ Academic Books

· Expert in Xenotransplantation Immunology and Ethical Regulation

Prof. Shaoping Deng

M.D., Chief Physician, Doctoral Supervisor, Vice-Chair of the Scientific Committee

· Council Member, International Xenotransplantation Association (IXA)

· Nearly Two Decades of Research and Clinical Practice at the University of Pennsylvania and Massachusetts General Hospital (Harvard)

· Author of 150+ SCI-Indexed Papers; Principal Investigator on Multiple National Key R&D Programs

· Former President, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

· Expert in Organ Transplantation and Immune Tolerance Induction

Prof. Dengke Pan

Ph.D., Founder & Chair, ClonOrgan Biotech; Senior Principal Investigator (National Second-Level, China), and Doctoral Supervisor

· Council Member, Asian Xenotransplantation Association (AXA)

· Pioneer in Developing China's First Cloned Pig and GGTA1-Knockout (GTKO) Pig

· Published 110+ scientific papers and holds multiple invention patents

· Recipient of the National Science and Technology Progress Award; Principal Investigator on National Key Research Programs

· Expert in Gene-Engineered Pig Models and Xenotransplantation Applications

Prof. Gang Chen

M.D., Distinguished Professor (National Second-Level, China), Chief Physician, Doctoral Supervisor

· Deputy Director, Key Laboratory of Organ Transplantation (Ministry of Education, National Health Commission & Chinese Academy of Medical Sciences)

· Achieved a record-setting breakthrough in porcine kidney-to-primate transplantation in Asia

· Director, Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology

· Deputy Editor-in-Chief, Chinese Journal of Organ Transplantation

· Expert in Rejection Management and Immune Risk Control in Xenotransplantation

Prof. Yi Wang

M.D., Distinguished Professor (National Second-Level, China), Senior Chief Physician (National First-Level, China), Doctoral Supervisor

· Director, Institute of Transplantation Medicine, Second Affiliated Hospital of Hainan Medical University

· Director, National Key Laboratory for Tropical Disease Prevention and Control (National Health Commission, China)

· Chair, Dialysis and Transplantation Branch, Chinese Society of Biomedical Engineering (CSBME)

· Dedicated to bringing transplantation immunology achievements into clinical practice in China

· Expert in Clinical Translation and Applications of Xenotransplantation

Prof. Hidetaka Hara

M.D., Ph.D.

· Professor, Institute of Transplantation Medicine, Second Affiliated Hospital of Hainan Medical University

· Council Member, International Xenotransplantation Association (IXA, 2023–2025)

· Editorial Board Member, Xenotransplantation; reviewer for The Lancet and Nature Communications

· Expert in Preclinical Large-Animal Transplantation Surgery

· Expert in Xenotransplantation and Immunobiology